Finely dice the onion into 1/4-inch pieces and measure out all your seasonings (salt, pepper, garlic powder, Worcestershire sauce). Preheat your oven to 350°F. This prep work takes just a few minutes and ensures you won't scramble during cooking.
Heat the vegetable oil in a large skillet over medium-high heat, then add the diced onions. Sauté for 2-3 minutes until softened and beginning to caramelize. Add the ground venison and cook, breaking it apart with a spoon, until deeply browned (about 5-7 minutes). I like to let the meat sit undisturbed for a minute or two between stirs to develop a nice crust—this creates much better flavor than constantly stirring. Once browned, stir in the Worcestershire sauce, salt, pepper, and garlic powder, cooking until any liquid evaporates (about 1-2 minutes). This layering of seasonings while the meat is hot ensures they distribute evenly throughout.
Remove the skillet from heat and let the venison mixture cool for 3-5 minutes until it's warm but no longer steaming. This cooling step is important—if you add mayonnaise to hot meat, it will break and separate. Once cooled slightly, stir in the mayonnaise until fully incorporated and the mixture is creamy and cohesive.
Slice the Hawaiian rolls in half horizontally and arrange the bottom halves cut-side up in a 9x13 inch baking dish (or similar size that fits all 12 roll halves snugly). Layer on the venison mixture from Step 3, then top each with a slice of sharp cheddar cheese. Place the top halves of the rolls on each slider. I prefer sharp cheddar because its bold flavor doesn't get lost against the rich, gamey venison—mild cheese would disappear.
In a small bowl, whisk together the melted butter, honey, and sesame seeds. Brush this mixture evenly over the tops of all the sliders. The honey adds a subtle sweetness that complements the savory venison and creates a beautiful glaze. Bake in the preheated 350°F oven for 10-15 minutes, until the tops are golden brown and the cheese begins to melt through the sides.
Remove the baking dish from the oven and let the sliders rest for 2-3 minutes before serving. This brief rest allows the cheese to set slightly and makes the sliders easier to handle without falling apart. Serve warm and enjoy the perfect bite of tender venison, melted cheese, and sweet Hawaiian rolls.